Liquid I.V.'s Science, Explained

What’s the science behind Liquid I.V.? Since the launch of our original product, Hydration Multiplier, the brand has garnered over 5,000 5-star reviews online and sold over 30 million servings worldwide. So why do people love Liquid I.V. so much? Because it works!

Below, we delve into what makes Liquid I.V. so uniquely effective at delivering hydration and nutrients into your bloodstream. Read on for a layperson’s translation of our science!

Liquid I.V. Medical Director, Dr. Brad Thomas, M.D.

What’s the scientific magic behind Liquid I.V.? Since the launch of our original product, the widely successful Hydration Multiplier, customers have been raving about its effectiveness, with over 5,000 5-star reviews online and over 30 million servings sold worldwide. People everywhere were shocked at how well our product delivers hydration…but we weren’t. Before Hydration Multiplier was even launched, we knew it would thrive in the marketplace because of the groundbreaking results of our clinical study.

So what came out of this uber-scientific study? Why have our products taken the country by storm? And what makes Liquid I.V. so uniquely effective at delivering hydration, supplements and nutrients into your bloodstream? Read below for a layperson’s translation of our clinical study. Spoiler alert: lots of science!

Oral Rehydration Solutions

The first thing this groundbreaking study reveals is that Liquid I.V. follows the guidelines set down by the World Health Organization (WHO) for oral rehydration solutions. An oral rehydration solution is the general term for a liquid mixture with a very specific ratio of sodium and glucose. ORS is extraordinary because it has been proven to allow increased absorption of water into the bloodstream. Generally used in cases of extreme dehydration, oral rehydration solutions have been adopted by the WHO as a quick, relatively inexpensive way to save lives. While our products are not medical formulas, and are designed to be used daily, they are also technically oral rehydration solutions.

Now, ORS saves lives, but it also contains unhealthy preservatives and tends to taste pretty heinous. Liquid I.V. gave ORS a makeover by removing the chemicals, making it taste delicious, and adding extra vitamins and nutrients—all while using that same essential ratio of sodium and glucose.

How exactly does this ratio provide so much more hydration than water alone? Read on for more science.

How it Works

Sodium and glucose have an “in” at the small intestine—it’s relatively easy for them to pass through and move on to the bloodstream from there. Water, however, isn’t so lucky. By itself, it’s turned away from the small intestine, and is instead sent to the large intestine. From there, water takes much longer to eventually travel to the bloodstream, and most of it turns to waste before it can even get there—leaving you dehydrated even after drinking a tall glass. The beauty of ORS is the sodium-glucose-water bond: they totally have each others’ backs. When water enters the body with its buddies sodium and glucose (in a very specific ratio), it piggybacks on its friends to pass through the small intestine and right into the bloodstream.

Boom! Once sodium and glucose make it possible for water to take a shortcut to the small intestine, that water becomes available to hydrate your body. Thanks, sodium and glucose!

Where Does CTT Come in?

“Cellular Transport Technology is a groundbreaking way to get nutrients into the body,” says orthopedic surgeon Dr. Brad Thomas, M.D., of Manhattan Beach. “We have all these products on the market that contain these great nutritional ingredients, with no way for the body to properly absorb them. CTT tackles this problem head-on, and it’s already changing the way things are done in the wellness industry.”

What a testimonial! So how does CTT work? When we created our product, we discovered that we could hack ORS’s special sodium-glucose delivery system and use it to get nutrients other than waterinto the bloodstream just as quickly and effectively. We introduced specific functional vitamins and nutrients, which are often difficult to absorb, into our formulas and found they were also absorbed much more efficiently! It was a revolutionary discovery for us, and for people with active lifestyles all over the world.

The clinical study determined that CTT is, indeed, highly effective. In one part of the study, scientists drew blood from 6 healthy adults, and then gave them a commercially available product that does not utilize CTT. This product contained two “marker ingredients.” After 15 minutes, they drew blood again. Then, the scientists measured the blood levels of those two marker ingredients. They followed the same process for Liquid I.V., which contains the same two ingredients.

The results were astonishing. Remarkably, within 15 minutes of ingestion, blood levels of one ingredient were substantially greater in all six subjects who had taken Liquid I.V.,and in five of six subjects for the other ingredient.

This meant the two marker ingredients show up in the bloodstream way more after taking Liquid I.V. than after taking the other product. The results from this pharmacokinetic study scientifically demonstrate the power of CTT to enhance absorption (faster and greater) of ingested ingredients from the gut into the bloodstream.

That says it all. Our breakthrough CTT is used in all Liquid I.V. products, giving you more fuel for life’s adventures.

Have questions? Feel free to reach out to info@liquid-iv.com.

Oral Rehydration Solutions

Liquid I.V. follows the guidelines set down by the World Health Organization (WHO) for Oral Rehydration Solution, or ORS. An ORS is the general term for a liquid mixture with a very specific ratio of sodium and glucose. The formula is extraordinary because it has been proven to allow increased absorption of water into the bloodstream. Generally used in cases of extreme dehydration, ORS has been adopted by the WHO as a quick, relatively inexpensive way to save lives. It has been tested extensively for over 50 years (see below for a link to one of many studies on ORS) and has been proven to be highly effective at optimizing hydration. While our products are not medical formulas, and are designed to be used daily, they are Oral Rehydration Solutions.

Liquid I.V. Medical Director, Dr. Brad Thomas

Now, a traditional ORS can save lives, but it also contains unhealthy preservatives and tends to taste pretty heinous. Liquid I.V. gave ORS a makeover by removing the chemicals, making it taste delicious, and adding extra vitamins and nutrients—all while using that same essential ratio of sodium and glucose. LIV can also transport nutrients in addition to water into the bloodstream, whereas ORS only delivers water. But we’ll get to that later.

So how exactly does ORS’s ratio provide so much more hydration than water alone? Read on for more science.

How it Works

Sodium and glucose have an “in” at the small intestine—it’s relatively easy for them to pass through and move on to the bloodstream from there. Water, however, isn’t so lucky. Water typically travels through the entire digestive system including the stomach, the small intestine, and the large intestine before getting into the bloodstream. Thus, alone, water takes much longer to eventually get to the bloodstream, and a lot of it turns to waste before it can even get there. The beauty of ORS is the sodium-glucose-water bond: they totally have each other’s backs. When water enters the body with its buddies sodium and glucose (in a very specific ratio), it piggybacks on its friends to pass through the small intestine and right into the bloodstream.

Boom! Once sodium and glucose make it possible for water to take a shortcut into the bloodstream on a cellular level, that water becomes available to hydrate your body. Thanks, sodium and glucose!

Where Does CTT Come in?

Our proprietary Cellular Transport Technology (CTT™) builds upon the science of ORS. When we created our product, we discovered that we could utilize ORS’s special sodium-glucose delivery system and use it to get nutrients in addition to water into the bloodstream just as quickly and effectively. This is CTT™. We introduced key functional ingredients like those in Liquid I.V. Sleep, which are often difficult to absorb, into our formulas and found they were also absorbed much more efficiently—just like water in an ORS solution. It was a revolutionary discovery for us, and for people with active lifestyles all over the world.

Here’s an example of just how exciting it was: when the bicycle first became available, people were thrilled—now they could get from place to place much faster and with much less effort than walking. But then the automobile was invented, and the game was officially changed. The scale of distance, comfort and convenience that was available to people became much larger. People could now carry not just themselves, but other things like food, materials and other people, across vast distances. There was nothing wrong with the bicycle, but now the car was the best way to travel! Now, think of ORS as a bicycle, and think of CTT™ as the newly-invented engine of the car, able to carry and deliver more items to its final destination—with a lot more comfort and safety to boot.

Wellness experts are on board. “Cellular Transport Technology is a groundbreaking way to get nutrients into the body,” says Liquid I.V. Medical Director, world-renowned orthopedic surgeon Dr. Brad Thomas, M.D. “We have all these products on the market that contain great nutritional ingredients—if the body could only absorb them properly. CTT™ tackles this problem head-on, and it’s already changing the way things are done in the wellness industry.”

All Liquid I.V. products utilize CTT™, so stay tuned for exciting future life-hacking line extensions!

Super into all this science? Below is a study on oral rehydration solutions, for further reading:

UNICEF-WHO report, “Reduced Osmolarity, Oral Rehydration Solution (ORS) Formulation,” 2001

Plus, check out our article on ORS.

Still have questions? Feel free to reach out to info@liquid-iv.com.

Wellness Center

HYDRATION MULTIPLIER
Lemon Lime

HYDRATION MULTIPLIER
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Passion Fruit

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Wellness Center

HYDRATION MULTIPLIER
Lemon Lime

HYDRATION MULTIPLIER
Açaí Berry

HYDRATION MULTIPLIER
Passion Fruit

HYDRATION MULTIPLIER
Variety Pack




4 Responses

Samantha
Samantha

February 28, 2019

Hi Marney,
Samantha here, from Liquid I.V. So glad you love the product!
Great questions. Our product is based on Oral Rehydration Solution (ORS), a formula recommended by the World Health Organization that has been tested extensively for over 50 years to optimize hydration. Below is an example of one of many scientific articles written about ORS, for your further reading. Our proprietary Cellular Transport Technology (CTT) builds upon ORS, and is a brand-new delivery system that we created In addition, our products with CTT have been determined by an independent laboratory to have a similar osmolarity. Therefore, our products with CTT optimize hydration like ORS but taste better and don’t have preservatives. Our study is supplemental to the years of testing that has been done on ORS, and while our first study had a small number of people participating (which is often the case with initial studies), the fact that there was statistical evidence of enhanced absorption is even more remarkable.This is our very first study, and there will be plenty more to come.
Have a great day!

UNICEF-WHO report, “Reduced Osmolarity, Oral Rehydration Solution (ORS) Formulation,” 2001, available at: http://apps.who.int/iris/ 2
bitstream/10665/67322/1/WHO_FCH_CAH_01.22.pdf.

Samantha
Samantha

February 28, 2019

Hi Sue,
Samantha here, from Liquid I.V.
We’re so glad you like the product!
Everyone is different, but we have not heard from anyone who has had a problem with water retention while using Liquid I.V. As always, if you have concerns, please consult your doctor.

Marney Ketterman
Marney Ketterman

February 28, 2019

I love this stuff as I have never been a big water drinker and have suffered from chronic dehydration as a result. Trying to rehydrate with the proper amount of water, I needed help! Liquid I.V. has been that help! But I would love to see a link to the original study on both the ORS and CTT. And citing a study as affirmative when only 6 adults were used is gutsy. That is an INCREDIBLY small population sample. Where are the stats the help me determine the validity of the study? Have there been more studies? Have they been published in any professional, peer-reviewed journals? This article left me with more questions than answers.

sue plummer
sue plummer

February 27, 2019

I have been using the liquid i.v. for a while now and I was wondering if this product could make you retain water?

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